GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UCEC | cis | rs199347 | 1 | rs199348 | chr7:23293098 | GPNMB | chr7:23286316-23314728:+ | -0.36 | -4.37 | 2.27E-5 | Parkinson's disease |
| UCEC | cis | rs199347 | 1 | rs199351 | chr7:23300049 | GPNMB | chr7:23286316-23314728:+ | -0.41 | -4.65 | 7.14E-6 | Parkinson's disease |
| UCEC | cis | rs1577917 | 1 | rs1995688 | chr6:86632319 | SNHG5 | chr6:86386726-86388451:- | -0.45 | -5.37 | 2.92E-7 | Response to antipsychotic treatment |
| UCEC | cis | rs1577917 | 1 | rs1999852 | chr6:86705738 | SNHG5 | chr6:86386726-86388451:- | -0.46 | -5.47 | 1.8E-7 | Response to antipsychotic treatment |
| UCEC | cis | rs2143950 | 1 | rs2010648 | chr14:35604892 | PPP2R3C | chr14:35554679-35591679:- | 0.53 | 4.86 | 2.91E-6 | Atopic dermatitis |
| UCEC | cis | rs6715284 | 1 | rs2019097 | chr2:202193463 | CFLAR | chr2:201980816-202029001:+ | -0.39 | -4.49 | 1.4E-5 | Rheumatoid arthritis |
| UCEC | cis | rs2028299 | 1 | rs2028299 | chr15:90374257 | AP3S2 | chr15:90373832-90456222:- | -0.46 | -4.57 | 1.02E-5 | Type 2 diabetes |
| UCEC | cis | rs9309473 | 1 | rs2056486 | chr2:73717567 | ALMS1P | chr2:73872046-73912692:+ | 0.53 | 6.29 | 3.29E-9 | Metabolite levels |
| UCEC | cis | rs10935120 | 1 | rs2056603 | chr3:134312749 | ANAPC13 | chr3:134196547-134204865:- | 0.39 | 4.39 | 2.1E-5 | Height |
| UCEC | cis | rs6542095 | 1 | rs2071373 | chr2:113540084 | PSD4 | chr2:113931560-113960676:+ | 0.47 | 4.4 | 1.99E-5 | Endometriosis |
| UCEC | cis | rs703842 | 1 | rs2072052 | chr12:58146719 | TSFM | chr12:58176536-58191367:+ | -0.42 | -4.45 | 1.65E-5 | Multiple sclerosis |
| UCEC | cis | rs4660306 | 1 | rs2077808 | chr1:45988115 | CCDC163P | chr1:45960581-45965646:- | -0.57 | -7.31 | 1.45E-11 | Homocysteine levels |
| UCEC | cis | rs965469 | 1 | rs2092990 | chr20:3346338 | ITPA | chr20:3190056-3204504:+ | -0.41 | -4.47 | 1.52E-5 | IFN-related cytopenia |
| UCEC | cis | rs10461617 | 1 | rs2113078 | chr5:56087190 | C5orf35 | chr5:56205103-56213010:+ | 0.54 | 5.69 | 6.27E-8 | Type 2 diabetes |
| UCEC | cis | rs10461617 | 1 | rs2113079 | chr5:56157951 | C5orf35 | chr5:56205103-56213010:+ | 0.63 | 7.08 | 4.97E-11 | Type 2 diabetes |